By Franz Joel Leong, Veronique Dartois, Thomas Dick
An annual demise toll of two million, coupled with emerging drug resistance, highlights the necessity for the advance of recent medicines, higher diagnostics, and a tuberculosis (TB) vaccine. Addressing those key concerns, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and educating within the box of TB. It comprises a hundred colour images and illustrations that convey readability to the knowledge provided. The atlas takes the weird method of overlaying a number of species histopathology, arguably the 1st and relatively in all likelihood the one source to take action. It offers an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal versions. The editors have compiled info that is helping TB scientists to differentiate among the good points of all significant animal types on hand and to exploit them with their strengths and boundaries in brain. The publication offers information for choosing the easiest animal model(s) to respond to particular questions and to check the efficacy of drug applicants.
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Extra info for A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis
Microwave-irradiated lung perfused with formalin. (a) LP. Thin fibrous septae (arrows) separate the lung parenchyma into distinct lobules. (b) MP. Alveolar spaces will only be well defined if the lung has been inflated prior to sectioning. (c) At high power Type I alveolar pneumocytes (T1) have central flat nuclei and broad cytoplasm, allowing them to cover 90% of the alveolar surface area. Type II pneumocytes (T2) are cuboidal cells with a central nucleus and prominent nucleolus. They are more common in number, but only cover about 5% of the alveolar surface and secrete surfactant.
2009). That MTB resides in lesions deep inside human tissue might cause another problem, this time for the drugs. Can the drugs actually reach the bacilli inside the lesions at the concentrations required to exert their antimicrobial activity? Very little is known about the penetration of anti-TB drugs into different lesion types in people and even less is know regarding lesion penetration in TB animal models. Some evidence suggests that penetration into lesions is drug and lesion type dependent.
Ziehl-Neelsen staining is used instead to detect MTB. Another hallmark of the pathogen is that it grows very slowly compared to other bacteria. Whereas E. coli divides once every 20 minutes, MTB divides once a day. The size of the MTB genome, about 4,000 genes, is similar to that of E. coli. , it requires oxygen for growth and is rod shaped). Simple culture media are available to grow MTB in the lab. So is a whole range of experimental animal models, from mice to monkeys, to grow the bacillus in vivo.