By William M. Lee, Roger Williams, Jean-Pierre Benhamou, Jacques Bernuau
Acute liver failure (ALF), or fulminant hepatic failure, is a special scientific syndrome that crosses clinical disciplines. a comparatively infrequent , ALF continues to be an incredible concentration of scientific and examine realization. With the arrival of transplantation, the significance of realizing administration of ALF has taken on a brand new urgency. during this first quantity devoted to ALF, the editors compile a exceptional staff of members to explain the etiology, pathology and therapy of this crucial syndrome. additionally coated are consensus concepts in liver transplantation for ALF sufferers, in addition to descriptions of synthetic and bioartificial liver support units. a piece on destiny remedies contains hepatocyte transplantation, auxiliary grafts and different transitority liver help. remarkable for the excessive point of the authors' services, this complete quantity may still turn out valuable.
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Extra info for Acute Liver Failure
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Intrinsic toxins and anoxia usually kill cells via a lytic process which ultimately involves loss of mitochondrial integrity with opening of a megachannel, that is the mitochondrial membrane permeability transition, with loss of mitochondria membrane potential and matrix constituents and with subsequent cytoskeletal changes, swelling and rupture of cell membrane (lysis) (Zahrebelski et al. 1995). This can be induced by oxidative stress, peroxides, calcium, GSH depletion and can be blocked by cyclosporin A.