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1987). The CD3 E chain, on the other hand, is not any more similar to the y or 6 chain than it is to several other members of the IgGSF, indicating a more distant 34 TIM HUNKAPILLER AND LEROY HOOD divergence. , 1987). However, the scores appear more to indicate that these molecules share homologous H-structures rather than a particularly close evolutionary relationship. The Thy-1 gene maps as well to band q23, but has no particular similarity to the CD3 gene. , 1987). , 1985). The normal ligand, and hence the function of the CD28 molecule, is still unknown.

EIK O . W . Q .. T V . S M . T . . . 9. The J-like sequences in nonrearranging IgGSF members. Shown for comparison are consensus J sequences for the three Ig families. Similarity to the J X consensus is indicated by dots. Gaps inserted to optimize alignment between J elements are indicated with dashes. , 1987), one without a disulfide loop. , 1986). Therefore, although the foreshortened nature of the second homology unit might suggest that it belongs to the H class of sequences, its similarity to the V-like region implies that it should also be classified as V-like.

However, the authors indicate homology of the N-terminal region of the Blast-1 chain with those of both the CD4 chain, which is classically V-like, and the MHC class I1 a chain, sequences that share no apparent similarity themselves. As discussed earlier, if these chains are truly homologous, it is difficult to explain why the CD4 and class I1 a chains do not appear related. Also, if the crystal structure of the MHC class I molecule proves to be a good model for the structure of the class I1 molecule, it is apparent that the N-terminal region of the class I1 a chain does not share any structural homology with Ig domains.

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