Download Apoptosis in Cardiac Biology by Jürgen Holtz M.D., Dorothea Darmer Ph.D. (auth.), Heribert PDF

Posted by

By Jürgen Holtz M.D., Dorothea Darmer Ph.D. (auth.), Heribert Schunkert, G. A. J. Riegger (eds.)

Apoptosis or programmed mobile demise is more and more thought of to be a significant factor within the improvement and development of heart problems. In sufferers with center failure the activation of apoptosis may end up within the lack of irreplaceable cardiac myocytes selling the medical process the syndrome. furthermore, within the coronary arteries irritation and apoptosis may well weaken severe constructions of the vessel wall resulting in plaque rupture and, for this reason, to myocardial infarction. Given those deleterious outcomes, it kind of feels nearly paradoxical that programmed mobilephone loss of life is an energetic method that, if initiated lower than physiological situations, is key for either coordinated tissue progress or destruction of malignant cells.
Apoptosis in Cardiac Biology, written by way of a crew of the world over popular researchers, supplies a well timed synopsis of uncomplicated mechanisms, mobile and structural pursuits and, ultimately, medical implications of programmed mobilephone dying within the center. The specialist authors of this quantity provide concise overviews on basic and cell-specific facets of programmed phone dying in cardiac myocytes and fibroblasts, in addition to in vascular tender muscle and endothelial cells. moreover, novel healing ideas bobbing up from the exceptional pathophysiological value of cardiac apoptosis are offered.
This complete evaluation of Apoptosis in Cardiac Biology could be of curiosity to either clinicians and uncomplicated researchers who're energetic within the fields of cardiology and atherosclerosis.

Show description

Read Online or Download Apoptosis in Cardiac Biology PDF

Similar biology books

Myeloproliferative Neoplasms: Biology and Therapy

This succinct source offers a terrific stability of the biology and useful healing ideas for traditional and non-classic BCR-ABL-negative myeloproliferative neoplasms. using present global healthiness association nomenclature, type, and diagnostic standards, foreign specialists have assembled to exhibit the main updated wisdom during this swiftly evolving box.

Evolutionary Biology and Ecology of Ostracoda: Theme 3 of the 13th International Symposium on Ostracoda (ISO97)

Ostracoda (Crustacea) are very likely first-class version organisms for evolutionary experiences, simply because they mix an intensive fossil list with a large contemporary distribution and as a result permit experiences on either styles and procedures resulting in extant variety. the most clinical domain names contributing theories, ideas, and knowledge to evolutionary biology are morphology (including ontogeny), palaeontology, genetics, and ecology, and to all of those points ostracods can give a contribution.

Additional resources for Apoptosis in Cardiac Biology

Sample text

S. B. Kribbs, F. J. Clubb, L. H. Michael, V. V. Didenko, P. J. Hornsby, Y. Seta, H. Oral, F. G. Spinale, and D. L. Mann. Pathophysiologically relevant concentrations of tumor necrosis factor-a promote progressive left ventricular dysfunction and remodeling in rats. Circulution 97: 1382-1391, 1998. Bradley, J. , D. R. Johnson, and J. S. Pober. Four different classes of inhibitors of receptormediated endocytosis decrease tumor necrosis factor-induced gene expression in human endothelial cells. J Immunol 150: 5544-5555, 1993.

Eur J Immunol25: 2183-2189, 1995. , D. Ferrari, M. Los, S. Wesselborg, and M. E. Peter. Apoptosis signaling by death receptors. Eur J Biochem 254: 439-459, 1998. , H. Morawietz, K. Hakim, H. R. Zerkowski, T. Eschenhagen, J. Holtz, and D. Darmer. Alternative splicing of the primary Fas transcript generating soluble Fas antagonists is suppressed in the failing human ventricular myocardium. Biochem Biophys Res Comm 239: 794798, 1997. Screaton, G. , J. Monkolsapaya, X. N. Xu, A. E. Cowper, A. J. McMichael, and J.

Goeddel. Prevention of constitutive TNF receptor signaling by silencer of death domains. Science 283: 543-546, 1999. Kagan, B. , R. L. Baldwin, D. Munoz, and B. J. Wisnieski. Formation of ion-permeable channels by tumor necrosis factor-a. Science 257: 1427-1430, 1993. , K. Kito, H. P. Nguyen, H. -K. , and E. T. Yeh. Identification of three sentrinization sites in PML. JBiol Chew 273: 26675-26682, 1998. , H. P. Nguyen, and E. T. Yeh. Preferential modification of nuclear proteins by a novel ubiquitin-like molecule.

Download PDF sample

Rated 4.58 of 5 – based on 41 votes